Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma

BACKGROUND: Kaposi's sarcoma (KS) is a vascular neoplasm characterized by the dysregulated expression of angiogenic and inflammatory cytokines. The driving force of the KS lesion, the KSHV-infected spindle cell, secretes elevated levels of vascular endothelial growth factor (VEGF), essential fo...

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Hlavní autoři: Jham, Bruno C., Ma, Tao, Hu, Jiadi, Chaisuparat, Risa, Friedman, Eitan R., Pandolfi, Pier Paolo, Schneider, Abraham, Sodhi, Akrit, Montaner, Silvia
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084756/
https://ncbi.nlm.nih.gov/pubmed/21559457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019103
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