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Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 β-lactamase
The TEM-1 β-lactamase confers bacterial resistance to penicillin antibiotics and has acquired mutations that permit the enzyme to hydrolyze extended spectrum cephalosporins or avoid inactivation by β-lactamase inhibitors. However, many of these substitutions have been shown to reduce activity agains...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644635/ https://ncbi.nlm.nih.gov/pubmed/18822298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.009 |
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