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Splice-site pairing is an intrinsically high fidelity process

The extensive alternative splicing in higher eukaryotes has initiated a debate whether alternative mRNA isoforms are generated by an inaccurate spliceosome or are the consequence of highly degenerate splice sites within the human genome. Here, we established a quantitative assay to evaluate the accu...

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Autori principali: Fox-Walsh, Kristi L., Hertel, Klemens J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644112/
https://ncbi.nlm.nih.gov/pubmed/19179398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813128106
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