Chronic NF-κB blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR

Nuclear factor-κB (NF-κB) plays an important role in hypertensive renal injury; however, its roles in perpetuating mitochondrial oxidative stress and renal dysfunction remain unclear. In this study, we assessed the effects of chronic NF-κB blockade with pyrrolidine dithiocarbamate (PDTC) on renal dy...

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Hlavní autoři: Elks, Carrie M., Mariappan, Nithya, Haque, Masudul, Guggilam, Anuradha, Majid, Dewan S. A., Francis, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643866/
https://ncbi.nlm.nih.gov/pubmed/19073636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90628.2008
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