The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends

Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PK(CS)) and t...

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Main Authors: Weterings, Eric, Verkaik, Nicole S., Keijzers, Guido, Florea, Bogdan I., Wang, Shih-Ya, Ortega, Laura G., Uematsu, Naoya, Chen, David J., van Gent, Dik C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643835/
https://ncbi.nlm.nih.gov/pubmed/19103741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00971-08
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