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The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends
Repair of DNA double-strand breaks (DSBs) is predominantly mediated by nonhomologous end joining (NHEJ) in mammalian cells. NHEJ requires binding of the Ku70-Ku80 heterodimer (Ku70/80) to the DNA ends and subsequent recruitment of the DNA-dependent protein kinase catalytic subunit (DNA-PK(CS)) and t...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Microbiology (ASM)
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643835/ https://ncbi.nlm.nih.gov/pubmed/19103741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00971-08 |
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