C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties

The Ku70/80 heterodimer binds to DNA ends and attracts other proteins involved in the non-homologous end-joining (NHEJ) pathway of DNA double-strand break repair. We developed a novel assay to measure DNA binding and release kinetics using differences in Förster resonance energy transfer (FRET) of t...

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Publicado no:Int J Mol Sci
Main Authors: Inagawa, Takabumi, Wennink, Thomas, Lebbink, Joyce H. G., Keijzers, Guido, Florea, Bogdan I., Verkaik, Nicole S., van Gent, Dik C.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555691/
https://ncbi.nlm.nih.gov/pubmed/32937838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186725
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