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Construction and Characterization of a Single-Cycle Chimeric Flavivirus Vaccine Candidate That Protects Mice against Lethal Challenge with Dengue Virus Type 2

We have previously described a novel flavivirus vaccine technology based on a single-cycle, capsid (C) gene-deleted flavivirus called RepliVAX. RepliVAX can be propagated in cells that express high levels of C but undergoes only a single cycle of infection in vaccinated hosts. Here we report that we...

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Detalhes bibliográficos
Main Authors: Suzuki, Ryosuke, Winkelmann, Evandro R., Mason, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643768/
https://ncbi.nlm.nih.gov/pubmed/19073745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01891-08
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