Novel Insect-Specific Eilat Virus-Based Chimeric Vaccine Candidates Provide Durable, Mono- and Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge

Most alphaviruses are mosquito borne and exhibit a broad host range, infecting many different vertebrates, including birds, rodents, equids, humans, and nonhuman primates. Recently, a host-restricted, mosquito-borne alphavirus, Eilat virus (EILV), was described with an inability to infect vertebrate...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Erasmus, Jesse H., Seymour, Robert L., Kaelber, Jason T., Kim, Dal Y., Leal, Grace, Sherman, Michael B., Frolov, Ilya, Chiu, Wah, Weaver, Scott C., Nasar, Farooq
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790933/
https://ncbi.nlm.nih.gov/pubmed/29187545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01274-17
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