RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

Rap1 small GTPases interact with Rap1-GTP-interacting adaptor molecule (RIAM), a member of the MRL (Mig-10/RIAM/Lamellipodin) protein family, to promote talin-dependent integrin activation. Here, we show that MRL proteins function as scaffolds that connect the membrane targeting sequences in Ras GTP...

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Hlavní autoři: Lee, Ho-Sup, Lim, Chinten James, Puzon-McLaughlin, Wilma, Shattil, Sanford J., Ginsberg, Mark H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Molecular Basis of Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643525/
https://ncbi.nlm.nih.gov/pubmed/19098287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807117200
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