Activation of Leukemia-associated RhoGEF by Gα(13) with Significant Conformational Rearrangements in the Interface

The transient protein-protein interactions induced by guanine nucleotide-dependent conformational changes of G proteins play central roles in G protein-coupled receptor-mediated signaling systems. Leukemia-associated RhoGEF (LARG), a guanine nucleotide exchange factor for Rho, contains an RGS homolo...

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Main Authors: Suzuki, Nobuchika, Tsumoto, Kouhei, Hajicek, Nicole, Daigo, Kenji, Tokita, Reiko, Minami, Shiro, Kodama, Tatsuhiko, Hamakubo, Takao, Kozasa, Tohru
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
主題:
Mechanisms of Signal Transduction
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643521/
https://ncbi.nlm.nih.gov/pubmed/19074425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804073200
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