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Gα(13)/PDZ-RhoGEF/RhoA Signaling Is Essential for Gastrin-Releasing Peptide Receptor–Mediated Colon Cancer Cell Migration

Gastrin-releasing peptide receptor (GRPR) is ectopically expressed in over 60% of colon cancers. GRPR expression has been correlated with increased colon cancer cell migration. However, the signaling pathway by which GRPR activation leads to increased cancer cell migration is not well understood. We...

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Foilsithe in:Mol Pharmacol
Main Authors: Patel, Maulik, Kawano, Takeharu, Suzuki, Nobuchika, Hamakubo, Takao, Karginov, Andrei V., Kozasa, Tohru
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576495/
https://ncbi.nlm.nih.gov/pubmed/24958816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.093914
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