Tyrosine phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression

We have documented that epidermal growth factor receptor protein tyrosine kinase (EGFR-PTK) signaling negatively affects intracellular trafficking and transduction efficiency of recombinant adeno-associated virus 2 (AAV2) vectors. Specifically, inhibition of EGFR-PTK signaling leads to decreased ubi...

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Hoofdauteurs: Zhong, Li, Li, Baozheng, Jayandharan, Giridhararao, Mah, Cathryn S., Govindasamy, Lakshmanan, Agbandje-McKenna, Mavis, Herzog, Roland W., Weigel-Van Aken, Kirsten A., Hobbs, Jacqueline A., Zolotukhin, Sergei, Muzyczka, Nicholas, Srivastava, Arun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643069/
https://ncbi.nlm.nih.gov/pubmed/18834608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.08.027
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