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Tyrosine phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression
We have documented that epidermal growth factor receptor protein tyrosine kinase (EGFR-PTK) signaling negatively affects intracellular trafficking and transduction efficiency of recombinant adeno-associated virus 2 (AAV2) vectors. Specifically, inhibition of EGFR-PTK signaling leads to decreased ubi...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643069/ https://ncbi.nlm.nih.gov/pubmed/18834608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.08.027 |
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