Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

Recombinant adeno-associated virus 2 (AAV2) vectors are in use in several Phase I/II clinical trials, but relatively large vector doses are needed to achieve therapeutic benefits. Large vector doses also trigger an immune response as a significant fraction of the vectors fails to traffic efficiently...

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Detalhes bibliográficos
Main Authors: Zhong, Li, Li, Baozheng, Mah, Cathryn S., Govindasamy, Lakshmanan, Agbandje-McKenna, Mavis, Cooper, Mario, Herzog, Roland W., Zolotukhin, Irene, Warrington, Kenneth H., Weigel-Van Aken, Kirsten A., Hobbs, Jacqueline A., Zolotukhin, Sergei, Muzyczka, Nicholas, Srivastava, Arun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2402387/
https://ncbi.nlm.nih.gov/pubmed/18511559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802866105
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