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Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
The Hedgehog (Hh) signaling pathway controls growth, cell fate decisions, and morphogenesis during development. Damage to Hh transduction machinery can lead to birth defects and cancer. The transmembrane protein Smoothened (Smo) relays the Hh signal and is an important drug target in cancer. Smo enr...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2642660/ https://ncbi.nlm.nih.gov/pubmed/19218434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813373106 |
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