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Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for their Lineage and Stage Specificity

We have assembled, annotated, and analyzed a database of over 1700 breakpoints from the most common chromosomal rearrangements in human leukemias and lymphomas. Using this database, we show that although the CpG dinucleotide constitutes only 1% of the human genome, it accounts for 40–70% of breakpoi...

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Detalhes bibliográficos
Main Authors: Tsai, Albert G., Lu, Haihui, Raghavan, Sathees C., Muschen, Markus, Hsieh, Chih-Lin, Lieber, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642632/
https://ncbi.nlm.nih.gov/pubmed/19070581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.10.035
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