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The Structure-Specific Nicking of Small Heteroduplexes by the RAG Complex: Implications for Lymphoid Chromosomal Translocations
During V(D)J recombination, the RAG complex binds at recombination signal sequences and creates double-strand breaks. In addition to this sequence-specific recognition of the RSS, the RAG complex has been shown to be a structure-specific nuclease, cleaving 3′ overhangs and 3′ flaps, and, more recent...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692700/ https://ncbi.nlm.nih.gov/pubmed/17307402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2006.12.016 |
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