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Cytosines, but Not Purines, Determine Recombination Activating Gene (RAG)-induced Breaks on Heteroduplex DNA Structures: IMPLICATIONS FOR GENOMIC INSTABILITY

The sequence specificity of the recombination activating gene (RAG) complex during V(D)J recombination has been well studied. RAGs can also act as structure-specific nuclease; however, little is known about the mechanism of its action. Here, we show that in addition to DNA structure, sequence dictat...

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Autori principali: Naik, Abani Kanta, Lieber, Michael R., Raghavan, Sathees C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844206/
https://ncbi.nlm.nih.gov/pubmed/20051517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089631
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