Inhibition of Spinal Cytosolic Phospholipase A(2) Expression by an Antisense Oligonucleotide Attenuates Tissue Injury-Induced Hyperalgesia

Activation of the spinal phospholipase A(2) (PLA(2)) - cyclooxygenase (COX) – prostaglandin signaling pathway is widely implicated in nociceptive processing. Although the role of spinal COX isoforms in pain signal transmission has been extensively characterized, our knowledge of PLA(2) enzymes in th...

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Hauptverfasser: Kim, David H., Fitzsimmons, Bethany, Hefferan, Michael P., Svensson, Camilla I., Wancewicz, Edward, Monia, Brett P., Hung, Gene, Butler, Madeline, Marsala, Martin, Hua, Xiao-Ying, Yaksh, Tony L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640426/
https://ncbi.nlm.nih.gov/pubmed/18511207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2008.04.033
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