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Intrathecal neurosteroids and a neurosteroid antagonist: Effects on inflammation-evoked thermal hyperalgesia and tactile allodynia

Neurosteroids regulate neuronal excitability though binding sites associated with the ionotropic γ-aminobutyric acid (GABA(A)) receptor. We sought to characterize the spinal analgesic actions in rats of two 5α-reduced neurosteroids, allopregnanolone and alphaxalone, on nociceptive processing and to...

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Bibliografiske detaljer
Main Authors: Svensson, Elin, Persson, Josefin, Fitzsimmons, Bethany, Yaksh, Tony L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761066/
https://ncbi.nlm.nih.gov/pubmed/23707652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.05.027
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