Antisense oligonucleotide therapy for neurodegenerative disease

Neurotoxicity from accumulation of misfolded/mutant proteins is thought to drive pathogenesis in neurodegenerative diseases. Since decreasing levels of proteins responsible for such accumulations is likely to ameliorate disease, a therapeutic strategy has been developed to downregulate almost any ge...

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Bibliografiske detaljer
Main Authors: Smith, Richard A., Miller, Timothy M., Yamanaka, Koji, Monia, Brett P., Condon, Thomas P., Hung, Gene, Lobsiger, Christian S., Ward, Chris M., McAlonis-Downes, Melissa, Wei, Hongbing, Wancewicz, Ed V., Bennett, C. Frank, Cleveland, Don W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1518790/
https://ncbi.nlm.nih.gov/pubmed/16878173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25424
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