Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms

Prostaglandin D(2) (PGD(2)) and its receptor chemoattractant receptor homologous molecule expressed on T(h)2 cells (CRTH2) have been implicated in the pathogenesis of numerous allergic diseases. We investigated the role of PGD(2) and CRTH2 in allergic cutaneous inflammation by using a highly potent...

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Autores principales: Boehme, Stefen A., Chen, Edward P., Franz-Bacon, Karin, Šášik, Roman, Sprague, L. James, Ly, Tai Wei, Hardiman, Gary, Bacon, Kevin B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Original Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638839/
https://ncbi.nlm.nih.gov/pubmed/19066315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxn118
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