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Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms

Prostaglandin D(2) (PGD(2)) and its receptor chemoattractant receptor homologous molecule expressed on T(h)2 cells (CRTH2) have been implicated in the pathogenesis of numerous allergic diseases. We investigated the role of PGD(2) and CRTH2 in allergic cutaneous inflammation by using a highly potent...

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Библиографические подробности
Главные авторы: Boehme, Stefen A., Chen, Edward P., Franz-Bacon, Karin, Šášik, Roman, Sprague, L. James, Ly, Tai Wei, Hardiman, Gary, Bacon, Kevin B.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638839/
https://ncbi.nlm.nih.gov/pubmed/19066315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxn118
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