CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation

Prostaglandin D(2), the ligand for the G protein-coupled receptors DP1 and CRTH2, has been implicated in the pathogenesis of the allergic response in diseases such as asthma, rhinitis, and atopic dermatitis. This prostanoid also fulfills a number of physiological, anti-inflammatory roles through its...

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Main Authors: Lukacs, Nicholas W., Berlin, Aaron A., Franz-Bacon, Karin, Šášik, Roman, Sprague, L. James, Ly, Tai Wei, Hardiman, Gary, Boehme, Stefen A., Bacon, Kevin B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584886/
https://ncbi.nlm.nih.gov/pubmed/18757520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90351.2008
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