Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury

The antibiotic trovafloxacin (TVX) has caused severe idiosyncratic hepatotoxicity in people, whereas levofloxacin (LVX) has not. Mice cotreated with TVX and lipopolysaccharide (LPS), but not with LVX and LPS, develop severe hepatocellular necrosis. Mice were treated with TVX and/or LPS, and hepatic...

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Main Authors: Shaw, Patrick J., Ditewig, Amy C., Waring, Jeffrey F., Liguori, Michael J., Blomme, Eric A., Ganey, Patricia E., Roth, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Systems Toxicology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638649/
https://ncbi.nlm.nih.gov/pubmed/18930950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn205
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