Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic Hepatotoxicity

Therapy employing the fluoroquinolone antibiotic, trovafloxacin (TVX) was curtailed due to idiosyncratic hepatotoxicity. Previous studies in mice showed that a nonhepatotoxic inflammatory stress induced by tumor necrosis factor α (TNF) synergized with a nonhepatotoxic dose of TVX to cause liver inju...

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Autores principales: Shaw, Patrick J., Beggs, Kevin M., Sparkenbaugh, Erica M., Dugan, Christine M., Ganey, Patricia E., Roth, Robert A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Immunotoxicology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742585/
https://ncbi.nlm.nih.gov/pubmed/19638433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp163
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