Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example

Idiosyncratic drug reactions (IDRs) are poorly understood, unpredictable, and not detected in preclinical studies. Although the cause of these reactions is likely multi-factorial, one hypothesis is that an underlying inflammatory state lowers the tolerance to a xenobiotic. Previously used in an infl...

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Główni autorzy: Liguori, Michael J., Ditewig, Amy C., Maddox, Jane F., Luyendyk, James P., Lehman-McKeeman, Lois D., Nelson, David M., Bhaskaran, Vasanthi M., Waring, Jeffrey F., Ganey, Patricia E., Roth, Robert A., Blomme, Eric A. G.
Format: Artigo
Język:Inglês
Wydane: Molecular Diversity Preservation International (MDPI) 2010
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000109/
https://ncbi.nlm.nih.gov/pubmed/21151465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms11114697
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