Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury

The antibiotic trovafloxacin (TVX) has caused severe idiosyncratic hepatotoxicity in people, whereas levofloxacin (LVX) has not. Mice cotreated with TVX and lipopolysaccharide (LPS), but not with LVX and LPS, develop severe hepatocellular necrosis. Mice were treated with TVX and/or LPS, and hepatic...

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Main Authors: Shaw, Patrick J., Ditewig, Amy C., Waring, Jeffrey F., Liguori, Michael J., Blomme, Eric A., Ganey, Patricia E., Roth, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2009
Assuntos:
Systems Toxicology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638649/
https://ncbi.nlm.nih.gov/pubmed/18930950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn205
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