Inducible Nitric Oxide Synthase Inhibitor SD-3651 Reduces Proteinuria in MRL/lpr Mice Deficient in the NOS2 Gene

Several studies have demonstrated the effectiveness of arginine analog nitric oxide synthase (NOS) inhibitor therapy in preventing and treating murine lupus nephritis. However, MRL/MpJ-FAS(lpr) (MRL/lpr) mice lacking a functional NOS2 (inducible NOS [iNOS]) gene (NOS2(−/−)) develop proliferative glo...

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Main Authors: Njoku, Chinedu, Self, Sally E., Ruiz, Philip, Hofbauer, Ann F., Gilkeson, Gary S., Oates, Jim C.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637653/
https://ncbi.nlm.nih.gov/pubmed/18797415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.231/JIM.0b013e3181889e13
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