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Selective cyclooxygenase-2 inhibitor suppresses renal thromboxane production but not proliferative lesions in the MRL/lpr murine model of lupus nephritis
BACKGROUND: Proliferative lupus nephritis (LN) is marked by increased renal thromboxane (TXA(2)) production. Targeting the TXA(2) receptor or TXA(2) synthase effectively improves renal function in humans with LN and improves glomerular pathology in murine LN. This study was designed to address the f...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3022955/ https://ncbi.nlm.nih.gov/pubmed/20924284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MAJ.0b013e3181f56d2c |
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