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Peroxynitrite formation and decreased catalase activity in autoimmune MRL-lpr/lpr mice.

BACKGROUND: (MRL)-lpr/lpr mice spontaneously develop autoimmune disease characterized by arthritis and glomerulonephritis. Nitric oxide is postulated to play a role in the disease pathogenesis, as mice treated with the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine (NMMA) show markedly r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Keng, T., Privalle, C. T., Gilkeson, G. S., Weinberg, J. B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949981/
https://ncbi.nlm.nih.gov/pubmed/11071272
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