Clinical and Serologic Manifestations of Autoimmune Disease in MRL-lpr/lpr Mice Lacking Nitric Oxide Synthase Type 2

Nitric oxide (NO) is an important mediator of the inflammatory response. MRL–lpr/lpr mice overexpress inducible nitric oxide synthase (NOS2) and overproduce NO in parallel with the development of an autoimmune syndrome with a variety of inflammatory manifestations. In previous studies, we showed tha...

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Main Authors: Gilkeson, Gary S., Mudgett, John S., Seldin, Michael F., Ruiz, Phil, Alexander, Audrey A., Misukonis, Mary A., Pisetsky, David S., Weinberg, J. Brice
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1997
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199001/
https://ncbi.nlm.nih.gov/pubmed/9236188
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