Solution Structures of Chemoenzymatically Synthesized Heparin and Its Precursors

We report the first chemoenzymatic synthesis of the stable isotope-enriched heparin from a uniformly labeled [(13)C,(15)N]N-acetylheparosan (-GlcA(1,4)GlcNAc-) prepared from E. coli K5. Glycosaminoglycan (GAG) precursors and heparin were formed from N-acetylheparosan by the following steps: chemical...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Zhenqing, McCallum, Scott A., Xie, Jin, Nieto, Lidia, Corzana, Francisco, Jiménez-Barbero, Jesús, Chen, Miao, Liu, Jian, Linhardt, Robert J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637250/
https://ncbi.nlm.nih.gov/pubmed/18767845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8026345
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