Structurally Informative Tandem Mass Spectrometry of Highly Sulfated Natural and Chemoenzymatically Synthesized Heparin and Heparan Sulfate Glycosaminoglycans

The highly sulfated glycosaminoglycan oligosaccharides derived from heparin and heparan sulfate have been a highly intractable class of molecules to analyze by tandem mass spectrometry. Under the many methods of ion activation, this class of molecules generally exhibits SO(3) loss as the most signif...

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Bibliographic Details
Main Authors: Kailemia, Muchena J., Li, Lingyun, Xu, Yongmei, Liu, Jian, Linhardt, Robert J., Amster, I. Jonathan
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2013
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617343/
https://ncbi.nlm.nih.gov/pubmed/23429520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.026880
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