Heavy heparin: A stable isotope-enriched, chemoenzymatically-synthesized, poly-component drug

Heparin is a highly sulfated, complex polysaccharide and widely used anticoagulant pharmaceutical. In this work, we chemoenzymatically synthesized perdeuteroheparin from biosynthetically enriched heparosan precursor obtained from microbial culture in deuterated medium. Chemical de-N-acetylation, che...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Cress, Brady F., Bhaskar, Ujjwal, Vaidyanathan, Deepika, Williams, Asher, Cai, Chao, Liu, Xinyue, Fu, Li, M-Chari, Vandhana, Zhang, Fuming, Mousa, Shaker A., Dordick, Jonathan S., Koffas, Mattheos A. G., Linhardt, Robert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461503/
https://ncbi.nlm.nih.gov/pubmed/30870573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201900768
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