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Chemoenzymatic synthesis of the next generation of ultralow MW heparin therapeutics
Heparin, a sulfated glycosaminoglycan, is a widely used injectable anticoagulant. This polysaccharide is a natural product extracted from porcine intestinal tissue. A specific pentasaccharide sequence is responsible for heparin’s high affinity towards anti-thrombin III, which undergoes a conformatio...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3320513/ https://ncbi.nlm.nih.gov/pubmed/22393937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.11.185 |
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