DNA epitope vaccine containing complement component C3d enhances anti-amyloid-β antibody production and polarizes the immune response towards a Th2 phenotype

We have engineered a DNA epitope vaccine that expresses 3 self-B cell epitopes of Aβ(42) (3Aβ(1−11)), a non-self T helper (Th) cell epitope (PADRE), and 3 copies of C3d (3C3d), a component of complement as a molecular adjuvant, designed to safely reduce CNS Aβ. Immunization of mice with 3Aβ(1−11)-PA...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Movsesyan, Nina, Mkrtichyan, Mikayel, Petrushina, Irina, Ross, Ted M., Cribbs, David H., Agadjanyan, Michael G., Ghochikyan, Anahit
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637203/
https://ncbi.nlm.nih.gov/pubmed/18838175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2008.08.016
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados