Anti-Aβ(1–11) Antibody Binds to Different β-Amyloid Species, Inhibits Fibril Formation, and Disaggregates Preformed Fibrils but Not the Most Toxic Oligomers

Different strategies proposed as therapy for Alzheimer disease (AD) have aimed to reduce the level of toxic forms of Aβ peptide in the brain. Here, we directly analyze the therapeutic utility of the polyclonal anti-Aβ(1–11) antibody induced in 3xTg-AD mice vaccinated with the second generation proto...

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Detalhes bibliográficos
Main Authors: Mamikonyan, Grigor, Necula, Mihaela, Mkrtichyan, Mikayel, Ghochikyan, Anahit, Petrushina, Irina, Movsesyan, Nina, Mina, Erene, Kiyatkin, Anatoly, Glabe, Charles G., Cribbs, David H., Agadjanyan, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435219/
https://ncbi.nlm.nih.gov/pubmed/17545160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700088200
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