Mannan-Abeta(28 )conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice

BACKGROUND: New pre-clinical trials in AD mouse models may help to develop novel immunogen-adjuvant configurations with the potential to avoid the adverse responses that occurred during the clinical trials with AN-1792 vaccine formulation. Recently, we have pursued an alternative immunization strate...

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Detalhes bibliográficos
Main Authors: Petrushina, Irina, Ghochikyan, Anahit, Mkrtichyan, Mikayel, Mamikonyan, Grigor, Movsesyan, Nina, Ajdari, Rodmehr, Vasilevko, Vitaly, Karapetyan, Adrine, Lees, Andrew, Agadjanyan, Michael G, Cribbs, David H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567310/
https://ncbi.nlm.nih.gov/pubmed/18823564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-5-42
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