Alzheimer's Disease Peptide Epitope Vaccine Reduces Insoluble But Not Soluble/Oligomeric Aβ Species in Amyloid Precursor Protein Transgenic Mice

Active vaccination of elderly Alzheimer's disease (AD) patients with fibrillar amyloid-β peptide (Aβ(42)), even in the presence of a potent Th1 adjuvant, induced generally low titers of antibodies in a small fraction (∼20% responders) of those that received the AN-1792 vaccine. To improve the i...

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Main Authors: Petrushina, Irina, Ghochikyan, Anahit, Mktrichyan, Mikayel, Mamikonyan, Gregory, Movsesyan, Nina, Davtyan, Hayk, Patel, Archita, Head, Elizabeth, Cribbs, David H., Agadjanyan, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366938/
https://ncbi.nlm.nih.gov/pubmed/18003852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3201-07.2007
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