Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH(2))(m,n)]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity

Dimeric opioid analogues linked to a pyrazinone platform, 3-[Tyr-NH(CH(2))(m)]-6-[Tyr-NH(CH(2))(n)]-2(1H)-pyrazinone (n, m = 3 or 4) and their corresponding Dmt derivatives were synthesized. Whereas the Try-containing compounds were essentially inactive, the Dmt derivatives exhibited high affinity f...

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Hlavní autoři: Shiotani, Kimitaka, Li, Tingyou, Miyazaki, Anna, Tsuda, Yuko, Bryant, Sharon D., Ambo, Akihiro, Sasaki, Yusuke, Lazarus, Lawrence H., Okada, Yoshio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636969/
https://ncbi.nlm.nih.gov/pubmed/16949282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.08.079
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