Nalaganje...
Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH(2))(m,n)]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity
Dimeric opioid analogues linked to a pyrazinone platform, 3-[Tyr-NH(CH(2))(m)]-6-[Tyr-NH(CH(2))(n)]-2(1H)-pyrazinone (n, m = 3 or 4) and their corresponding Dmt derivatives were synthesized. Whereas the Try-containing compounds were essentially inactive, the Dmt derivatives exhibited high affinity f...
Shranjeno v:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2636969/ https://ncbi.nlm.nih.gov/pubmed/16949282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.08.079 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|