Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia

Liver X receptors (LXRs) are important regulators of cholesterol and lipid metabolism. LXR agonists have been shown to limit the cellular cholesterol content by inducing reverse cholesterol transport, increasing bile acid production, and inhibiting intestinal cholesterol absorption. Most of them, ho...

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Main Authors: Kratzer, Adelheid, Buchebner, Marlene, Pfeifer, Thomas, Becker, Tatjana M., Uray, Georg, Miyazaki, Makoto, Miyazaki-Anzai, Shinobu, Ebner, Birgit, Chandak, Prakash G., Kadam, Rajendra S., Calayir, Emine, Rathke, Nora, Ahammer, Helmut, Radovic, Branislav, Trauner, Michael, Hoefler, Gerald, Kompella, Uday B., Fauler, Guenter, Levi, Moshe, Levak-Frank, Sanja, Kostner, Gerhard M., Kratky, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636920/
https://ncbi.nlm.nih.gov/pubmed/18812595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800376-JLR200
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