Cholesteryl ester hydrolase activity is abolished in HSL macrophages but unchanged in macrophages lacking KIAA1363

Cholesteryl ester (CE) accumulation in macrophages represents a crucial event during foam cell formation, a hallmark of atherogenesis. Here we investigated the role of two previously described CE hydrolases, hormone-sensitive lipase (HSL) and KIAA1363, in macrophage CE hydrolysis. HSL and KIAA1363 e...

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Main Authors: Buchebner, Marlene, Pfeifer, Thomas, Rathke, Nora, Chandak, Prakash G., Lass, Achim, Schreiber, Renate, Kratzer, Adelheid, Zimmermann, Robert, Sattler, Wolfgang, Koefeler, Harald, Fröhlich, Eleonore, Kostner, Gerhard M., Birner-Gruenberger, Ruth, Chiang, Kyle P., Haemmerle, Guenter, Zechner, Rudolf, Levak-Frank, Sanja, Cravatt, Benjamin, Kratky, Dagmar
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2010
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936755/
https://ncbi.nlm.nih.gov/pubmed/20625037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004259
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