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Dual Roles of Brain Serine Hydrolase KIAA1363 in Ether Lipid Metabolism and Organophosphate Detoxification

Serine hydrolase KIAA1363 is an acetyl monoalkylglycerol ether (AcMAGE) hydrolase involved in tumor cell invasiveness. It is also an organophosphate (OP) insecticide-detoxifying enzyme. The key to understanding these dual properties was the use of KIAA1363 +/+ (wildtype) and −/− (gene deficient) mic...

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Detalhes bibliográficos
Main Authors: Nomura, Daniel K., Fujioka, Kazutoshi, Issa, Roger S., Ward, Anna M., Cravatt, Benjamin F., Casida, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423230/
https://ncbi.nlm.nih.gov/pubmed/18164358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2007.11.021
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