Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor

BACKGROUND: Nuclear localization of proteolytically formed intracellular fragment of ErbB4 receptor tyrosine kinase has been shown to promote cell survival, and nuclear localization of ErbB4 receptor has been described in human breast cancer. Tumor necrosis factor alpha converting enzyme (TACE) init...

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Main Authors: Määttä, Jorma A, Olli, Kaisa, Henttinen, Tiina, Tuittila, Minna T, Elenius, Klaus, Salmivirta, Markku
格式: Artigo
語言:Inglês
出版: BioMed Central 2009
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636757/
https://ncbi.nlm.nih.gov/pubmed/19171023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-10-5
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