Knockin of mutant PIK3CA activates multiple oncogenic pathways

The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to “knock in” PIK3CA mutations into human breast epithelial cells to identify new therapeutic targets associated with oncogenic PIK3CA. Mutant PIK3CA knockin cells were capable of epi...

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Xehetasun bibliografikoak
Egile Nagusiak: Gustin, John P., Karakas, Bedri, Weiss, Michele B., Abukhdeir, Abde M., Lauring, Josh, Garay, Joseph P., Cosgrove, David, Tamaki, Akina, Konishi, Hiroyuki, Konishi, Yuko, Mohseni, Morassa, Wang, Grace, Rosen, D. Marc, Denmeade, Samuel R., Higgins, Michaela J., Vitolo, Michele I., Bachman, Kurtis E., Park, Ben Ho
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2009
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636736/
https://ncbi.nlm.nih.gov/pubmed/19196980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813351106
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