Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations

An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the isolation of human cancer cell lines that harbor this mutation thereby limiting funct...

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Detalhes bibliográficos
Main Authors: Lauring, Josh, Cosgrove, David P., Fontana, Stefani, Gustin, John P., Konishi, Hiroyuki, Abukhdeir, Abde M., Garay, Joseph P., Mohseni, Morassa, Wang, Grace M., Higgins, Michaela, Gorkin, David, Reis, Marcelo, Vogelstein, Bert, Polyak, Kornelia, Cowherd, Meredith, Buckhaults, Phillip J., Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042798/
https://ncbi.nlm.nih.gov/pubmed/20101210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.516
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