Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations

An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the isolation of human cancer cell lines that harbor this mutation thereby limiting funct...

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Bibliografiset tiedot
Päätekijät: Lauring, Josh, Cosgrove, David P., Fontana, Stefani, Gustin, John P., Konishi, Hiroyuki, Abukhdeir, Abde M., Garay, Joseph P., Mohseni, Morassa, Wang, Grace M., Higgins, Michaela, Gorkin, David, Reis, Marcelo, Vogelstein, Bert, Polyak, Kornelia, Cowherd, Meredith, Buckhaults, Phillip J., Park, Ben Ho
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042798/
https://ncbi.nlm.nih.gov/pubmed/20101210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.516
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